http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-3539730-B2
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C51-367 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C67-347 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C51-347 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C65-03 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C67-347 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C67-343 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B01J23-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C51-367 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B61-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C69-734 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C69-732 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C51-353 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C51-347 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C65-21 |
| filingDate | 1993-08-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2004-07-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2004-07-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-3539730-B2 |
| titleOfInvention | Method for producing cinnamic acid derivatives |
| abstract | PCT No. PCT/EP93/02317 Sec. 371 Date Apr. 28, 1994 Sec. 102(e) Date Apr. 28, 1994 PCT Filed Aug. 27, 1993 PCT Pub. No. WO94/05621 PCT Pub. Date Mar. 17, 1994.A novel process for the manufacture of a cinnamic acid derivative of the formula <IMAGE> I wherein R1 signifies hydrogen or C1-8-alkyl and R2 signifies hydrogen, C1-10-alkyl, C1-10-hydroxyalkyl or C1-4-alkoxy-C1-10-alkyl, is described in which a 4-R1O-halobenzene is reacted with acrylic add or an acrylic acid ester CH2=CHCOOR2 using a heterogeneous palladium catalyst in the presence of the alkanoic acid ammonium salt formed from a C2-5-alkanoic acid and an aliphatic mono-, di- or trialkylamine or heterocyclic amine. In the case of the manufacture of the cinnamic acid derivative I in which R2 signifies hydrogen, the reaction can be carried out in the presence of the amine in place of the alkanoic acid ammonium salt. A further aspect of the described invention comprises reacting the 4-R1O-iodobenzene with the product of the Michael addition of an acrylic acid ester CH2=CHCOOR2', wherein R2' has the above significance of R2 except hydrogen, with an aliphatic or heterocyclic primary of secondary amine using a heterogeneous palladium catalyst and in the presence of a C2-5-alkanoic add in order to manufacture the above cinnamic add derivatives with the exception of the substituted cinnamic acid itself. In view of their UV-B absorbing properties the thus-manufactured cinnamic acid derivatives are suitable as UV-B filters for cosmetic agents, e.g. sunscreen agents. |
| priorityDate | 1992-09-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
| Predicate | Subject |
|---|---|
| isDiscussedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID455661786 |
Total number of triples: 24.