http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2997536-B2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_983fa366d54b080542742d72951c002c |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D319-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-55 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D243-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-495 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-06 |
| filingDate | 1990-11-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2000-01-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5eb25fb6ec988d8d08590872fe86539c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b1092cdf08189f9e65aebedc08b62937 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_04f5d180fa318ad06e56a1d2d80b1228 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_291e3c90ec6bb965af37c0289f0df6ca |
| publicationDate | 2000-01-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2997536-B2 |
| titleOfInvention | Pantothenic acid derivative |
| abstract | NEW MATERIAL:A compound of formula I {R<1> and R<2> are each H or protective group for OH; R<3> is (aromatic group-substituted)5-25C monovalent aliphatic hydrocarbon group or NH-R<4> [R<4> is (aromatic group-substituted)5-25C monovalent aliphatic hydrocarbon group); (m) is 2 or 3; (n) is 1-4}. EXAMPLE:1-Hexanoyl-4-{1-oxo-3-[N-(1-oxo-2,4-diacetoxy-3,3-dimethylbutyl) amino]propyl}piperazine. USE:Having inhibitory activity for acyl CoA-cholesterol-acyl transferase, thus useful for the therapies for hyperlipemia, arteriosclerosis, etc. PREPARATION:The objective compound of the formula I can be obtained by reaction between (A) a compound of formula II (R<11> and R<12> are each protected OH) and (B) a compound of formula R<3>-COZ<1> (Z<1> is H, halogen, alkoxy, etc.) or formula R<4>-NCO using, as necessary, a catalyst or reaction promoter in a solvent such as methylene chloride at temperatures ranging from -78 deg.C to the boiling point of the solvent. |
| priorityDate | 1989-11-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 209.