Predicate |
Object |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2740-15043 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2740-16043 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2510-00 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-4702 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-2878 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0646 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0636 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-86 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-17 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-17 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
filingDate |
2020-08-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationDate |
2022-10-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
JP-2022544592-A |
titleOfInvention |
THERAPEUTIC IMMUNE CELLS WITH IMPROVED FUNCTIONS AND METHOD FOR PRODUCING SAME |
abstract |
The present disclosure provides immune cells with improved functions and properties. Immune cells that overexpress or ectopically express an autophagy modulator are provided. Increased expression of autophagy modulators can improve the function of T cells or NK cells expressing chimeric antigen receptors (CARs). For example, CAR-T cells ectopically expressing ATG5 or ATG7 show improved stimulation in response to antigen. |
priorityDate |
2019-08-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |