| abstract |
The present invention relates to applications of polypeptides or derivatives thereof, particularly antitumor polypeptide drugs (amino acid sequence shown in SEQ ID NO: 1, or deletion of one or more amino acids in the amino acid sequence shown in SEQ ID NO: 1). amino acid sequences resulting from deletions, substitutions, additions and/or modifications). The polypeptide-based pharmaceuticals have significant advantages in drug target specificity, drug biological activity, drug toxic side effects, treatment cost, and the like. In the present invention, a polypeptide or derivative thereof capable of suppressing tumor cell activity and tumor metastasis is designed based on cytokines involved in the formation and maintenance of a stable tumor microenvironment, and this polypeptide or derivative thereof is designed. Applies to the production of antitumor drugs. |