| abstract |
The present invention provides anti-Fzd monoclonal antibodies and related compositions that can be used in any of a variety of therapeutic methods for the treatment of disease. In one embodiment, the present disclosure provides (i) CDRH1, CDRH2 and CDRH3 sequences as shown for any of the antibodies in Table 1; and/or (ii) CDRL1, CDRL2 and CDRL3 as shown for any of the antibodies in Table 1. An isolated antibody or antigen-binding fragment thereof that binds to one or more Frizzled receptors comprising a sequence comprising the sequence, or a variant of said antibody or antigen-binding fragment thereof comprising one or more amino acid alterations and wherein said variant comprises less than 8 amino acid substitutions in said CDR sequences. |