| abstract |
Inhibitors, such as antibodies, and antigen-binding moieties thereof that selectively bind to the complex of LTBP1-TGFβ and / or LTBP3-TGFβ are disclosed herein. The application also provides methods of using these inhibitors, for example, to inhibit TGFβ activation and to treat subjects suffering from TGFβ-related disorders, such as fibrotic conditions. Also provided is a method of selecting a context-dependent or context-independent isoform-specific TGFβ inhibitor for a subject in need thereof. |