| abstract |
The present invention relates to a bifunctional compound having a function of recruiting and degrading an endogenous protein to E3 ubiquitin ligase, and a method for using the same. More specifically, the present specification provides specific proteolytic targeting chimeric molecules (PROTACs) that have been found to be useful as modulators of ubiquitination of various targeted polypeptides and other proteins. And, in particular, the androgen receptor of the slice variant of LBD-deficient AR, represented as AR-V7, is degraded and / or otherwise inhibited by the compounds described herein. |