| abstract |
Rodents (such as mice and rats) that have been genetically modified at the endogenous Scn9a locus to include an extrinsic Scn nucleotide sequence, such as the coding sequence for the human SCN2A gene, are disclosed herein. Also disclosed are methods and compositions useful for making such rodents, as well as methods of using such rodents for producing anti-NaV1.7 antibody. [Selection diagram] None |