| abstract |
The present invention provides compounds, compositions thereof, and methods of using them for inhibiting TYK2 and treating TYK2-mediated disorders. The pseudokinase binding pocket of TYK2 contains multiple hydration sites, each of which is occupied by a molecule of water. Each of these water molecules has a stability rating associated with it. As used herein, the term "stability assessment" refers to a numerical calculation that includes the enthalpy, entropy, and free energy values associated with each water molecule. This stability assessment allows measurable determination of the relative stability of water molecules that occupy the hydration site in the TYK2 binding pocket. |