| abstract |
The present disclosure provides an anti-CD38 binding domain, a composition comprising an anti-CD38 binding domain, a nucleic acid encoding the anti-CD38 binding domain, and a method of using the anti-CD38 binding domain or composition for treating multiple myeloma. To. In one aspect, the composition comprises an anti-CD38 antigen binding domain, which is vhCDR1 having the amino acid sequence of SEQ ID NO: 2, vhCDR2 having the amino acid sequence of SEQ ID NO: 3, and the amino acid of SEQ ID NO: 4. A variable heavy domain (VH) containing vhCDR3 having a sequence, a variable light domain containing vlCDR1 having the amino acid sequence of SEQ ID NO: 6, blCDR2 having the amino acid sequence of SEQ ID NO: 7, and blCDR3 having the amino acid sequence of SEQ ID NO: 8 ( VL) and. |