| abstract |
The present invention relates to a polypeptide that is covalently attached to a non-aromatic molecule scaffold such that two or more peptide loops reside between attachment points to the scaffold. In particular, the present invention describes a peptide that is a high affinity binder for integrin αvβ3. The present invention relates to a drug conjugate comprising the peptide, conjugated to one or more effectors and / or functional groups, a pharmaceutical composition comprising the peptide ligand and the drug conjugate, and a disease or disorder mediated by integrin αvβ3. Also includes the use of the peptide ligand and drug conjugate in the prevention, suppression, or treatment of. [Selection diagram] None |