http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2022517931-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-704 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0085 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-573 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-113 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-113 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-706 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-573 |
| filingDate | 2019-01-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-03-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2022517931-A |
| titleOfInvention | A drug transfer platform using a W / O / W triolein emulsion that enhances the permeability of the blood-brain barrier |
| abstract | In the present invention, the active ingredient is a triolein emulsion having an internal aqueous phase / oil phase / external aqueous phase (W / O / W) type structure in which the oil phase droplet contains triolein and the water droplet is enclosed inside the oil phase droplet. The present invention relates to a composition for drug transfer to a tissue having an intimately linked portion and a method for producing the same, and the triolein emulsion having a W / O / W type structure according to the present invention exhibits the BBB opening activity of triolein as it is. It is also used as a composite formulation because it contains an aqueous phase droplet in an oil phase droplet, contains a surfactant, is excellent in safety, and can further encapsulate a fat-soluble drug in the oil phase droplet. Thus, the drug can be more effectively transmitted to tissues having close junctions such as the brain, testicles, and retina. |
| priorityDate | 2019-01-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 41.