| abstract |
To prepare an isolated binding molecule (eg, an antibody) or an antigen binding fragment thereof that can be used as a therapeutic agent for treating and / or preventing a cell-related disease expressing claudin 18.2. The above-mentioned diseases include gastric cancer, esophageal cancer, pancreatic cancer, lung cancer, ovarian cancer, colon cancer, liver cancer, head and neck cancer and bile sac cancer. including. Adjuvant treatment as a single agent (eg, nude antibody) or against other antigen-binding anticancer agents such as immune checkpoint inhibitors (eg, anti-CTLA-4 and anti-PD-1 / PD-L1 monoclonal antibodies) And / or as a combination therapy in which the anti-clodin 18.2 antibody is administered before, after, or simultaneously with the chemotherapeutic method, further describes a drug formulation comprising said composition for treating the disease. |