| abstract |
The present invention is one of a compound of formula (Ib') below, or a metabolite thereof or a pharmaceutically acceptable salt thereof, for use in treating and / or preventing cancer and / or dysplasia. Regarding. [Chemical 1] Here, R is independently hydrogen atom, halogen atom, -CN, hydroxyl, (C 1 to C 3 ) fluoroalkyl, (C 1 to C 3 ) fluoroalkoxy, (C 3 to C 6 ) cycloalkyl, -NO 2 , -NR 1 R 2 , (C 1 to C 4 ) Alkoxy, Phenoxy, -NR 1 -SO 2 -NR 1 R 2 , -NR 1 -SO 2 -R 1 , -NR 1 -C (= O) -R1, -NR 1 -C (= O) -NR 1 R 2 , -SO 2 -NR 1 R 2 , -SO 3 H, -O-SO 2 -OR 3 , -OP (= O) ( OR 3 ) (OR 4 ), -O-CH 2 -COOR3, (C 1 to C 3 ) alkyl, where the alkyl is optionally a hydroxyl group, -A- (CH 2 ) m -B. It may be mono- or di-substituted by the -NRaRb group or the-(O-CH 2 -CH 2 ) p -O-Ra group. The invention also relates to a compound of formula (IVb') or a pharmaceutically acceptable salt thereof for use in treating and / or preventing cancer and / or dysplasia. [Selection diagram] None |