| abstract |
SOLUTION: A compound having the structure of the formula (I), or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof is provided, and X 1 in the formula. , X 2 , and R 1 are as defined herein. Such compounds function as thyroid mimics and have utility for treating diseases such as neurodegenerative disorders and fibrotic disorders. Pharmaceutical compositions containing such compounds, as well as methods of their use and preparation, are also provided. [Chemical 1] [Selection diagram] None |