http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2022512650-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-94 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-92 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-567 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-565 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-78 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-005 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C40B40-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C40B50-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C40B10-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1089 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C40B40-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C40B40-08 |
| filingDate | 2019-10-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-02-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2022512650-A |
| titleOfInvention | Antibody library and method |
| abstract | The present disclosure relates to methods of producing antibody libraries, antibody libraries produced using such methods, and variant antibodies. Currently, the method of improving antibody binding (affinity maturation assay) is to screen a vast library of antibody variants (often> 10 10 ) to identify only a few variants with improved properties. To request. The present invention comprises obtaining nucleotide sequences of target antibody frameworks and complementarity determining regions and identifying motifs recognized by deamination somatic hypermutation enzymes. Next, a small library of variants incorporating one or more of these mutations is created. It was found that a relatively high proportion of variants had increased affinity. The technique of the present invention has been demonstrated with trastuzumab and cathepsin S antibodies, and variants produced are also claimed. [Selection diagram] None |
| priorityDate | 2018-10-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 198.