http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2022511761-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C40B30-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-047 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C40B40-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C40B40-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C40B50-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K7-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C40B70-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-047 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C40B40-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-00 |
| filingDate | 2019-11-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-02-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2022511761-A |
| titleOfInvention | Genetically encoded macrocyclic peptide library with pharmacophore |
| abstract | The present invention relates to a method of forming a macrocyclic peptide having a pharmacophore and the produced macrocyclic peptide, wherein the method comprises a peptide containing two thiol groups in the cysteine side chain, a reactive compound 1,5-dichloro. Includes a step of reacting with Pentandion-2,4. The reaction of the reactive compound with the peptide produces a 1,3-diketone-containing macrocyclic polypeptide. The macrocyclic compound having a 1,3-diketone group is then modified by reaction of the macrocycle with an alkyl or arylhydrazine group having a pharmacophore under benign aqueous conditions. Macrocycles are displayed in libraries such as phage display libraries and can be used to biopan for affinity for selected targets. |
| priorityDate | 2018-11-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 65.