| Predicate |
Object |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2430-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-70
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61F2310-00365
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61F2002-2817
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2300-414
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61F2002-2835
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2300-252 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-365
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-1875
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61F2-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/D01D5-003
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K33-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K33-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-54
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-56
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-58
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-3608
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08L67-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-446
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-46 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-46
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-58
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-54 |
| filingDate |
2019-12-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate |
2022-01-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
JP-2022511160-A |
| titleOfInvention |
Bone regeneration material with a cotton-shaped structure consisting of multiple electrospun fibers |
| abstract |
Disclosed is a bone regeneration material having a cotton-like structure composed of a plurality of electrolytically spun fibers in which BMP-2 is bound via a β-TCP binding peptide. Electrolytically spun fibers contain 25-65 vol% of β-TCP particles dispersed in the fibers, which exposes some of the β-TCP particles to the surface of the electrospun fibers and the rest of the β-TCP particles. Is embedded in the fiber without being exposed to the outside. The β-TCP-binding peptide fused with BMP-2 is bound to β-TCP particles such that BMP-2 connects to β-TCP particles on the surface of the fiber. BMP-2, in which the bone regeneration material is embedded in the bone defect site of the human body and is linked to β-TCP particles on the surface of the bone regeneration material, promotes cell proliferation and differentiation in the bone defect site. [Selection diagram] FIG. 7 |
| priorityDate |
2018-12-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |