| abstract |
The present invention belongs to the field of medicine and relates to RET inhibitors, pharmaceutical compositions thereof, and their use. In particular, the present invention comprises compounds having formula (I) or steric isomers, geometric isomers, tautomers, N-oxides, solvates, metabolites, pharmaceutically acceptable salts or prodrugs thereof. offer. The invention also comprises the manufacture of pharmaceutical compositions containing compounds, as well as pharmaceuticals for the treatment and prevention of RET-related diseases and conditions, including pain associated with, among other things, cancer, irritable bowel syndrome, and / or irritable bowel syndrome. With respect to the use of the compound and its pharmaceutical composition in. [Chemical 1] |