| abstract |
Disclosed are methods of treating fibrotic conditions using carborane and carborane analogs. Also disclosed are compounds containing dicarba-crossodedecabolan or dicarba-crossodedecabolan analogs. The compound can be, for example, an estrogen receptor β (ERβ) agonist. In some examples, the compound can be a selective ERβ agonist. By administering to a subject a therapeutically effective amount of one or more of the compounds or compositions disclosed herein, or pharmaceutically acceptable salts thereof, the treatment, prevention, or amelioration of cancer in the subject. Also provided herein are methods of suppressing tumor growth in a subject, treating inflammatory disease in a subject, treating neurodegenerative disease in a subject, treating psychiatric disorders in a subject, or a combination thereof. .. |