abstract |
Compound of formula (I) (In the formula, Ar 1 , R 21 , R 23 , R 24 , R 25 , R 26 , R 27 , A, X, Y and W are as defined herein). The compounds of the present invention are inhibitors of hematopoietic prostaglandin D synthase (H-PGDS) and may be useful in the treatment of Duchenne muscular dystrophy. Therefore, the present invention is further directed to a pharmaceutical composition comprising the compound of the present invention. The present invention also further relates to methods of inhibiting H-PGDS activity and the treatment of disorders associated therewith using compounds of the invention or pharmaceutical compositions comprising the compounds of the invention. |