| abstract |
The 3-carbonylamino-8-aminoisoquinoline compounds of formula (I); variants thereof and their use as HPK1 (hematopoietic precursor kinase 1) inhibitors are described. This compound is useful for treating HPK1-dependent disorders and enhancing immune response. Also described are methods of inhibiting HPK1, treating HPK1-dependent disorders, enhancing immune responses, and preparing 3-carbonylamino-8-aminoisoquinoline compounds. TIFF2022504080000984.tif39170 [Selection diagram] None |