abstract |
The present invention relates to a polysubstituted isoindoline compound represented by the general formula (I), a method for preparing the same, a pharmaceutical composition and an application thereof. Specifically, the polysubstituted isoindoline compound provided in the present invention has stronger antitumor activity and antitumor spectrum as a novel structural CRL4CRBNE3 ubiquitin ligase regulator and treats diseases related to CRL4CRBNE3 ubiquitin ligase. Can be used in the preparation of drugs to be used. |