| abstract |
The present disclosure is characterized by novel lipids and compositions containing them. The nanoparticle composition comprises novel lipids as well as additional lipids such as phospholipids, structural lipids, and PEG lipids. Nanoparticle compositions further comprising therapeutic and / or prophylactic agents such as RNA, for example, therapeutic and / or prophylactic agents to mammalian cells or organs for regulating polypeptide, protein, or gene expression. Useful for delivery. [Selection diagram] Fig. 1 |