| abstract |
PROBLEM TO BE SOLVED: To contain berberine or a salt thereof, in which deterioration of the transmittance of an ophthalmic composition is suppressed by repeating freezing and thawing of an ophthalmic composition containing the components (A), (B) and (D). An ophthalmic composition is provided. (A) Berberine or a salt thereof, (B) One or more selected from (B1) vitamin A and (B2) vitamin E, An ophthalmic composition containing (C) phenylephrine or a salt thereof, and (D) a nonionic surfactant. [Selection diagram] None |