| abstract |
An object of the present invention is to reduce the cytotoxicity of a cooling agent and/or to enhance the cooling sensation of a cooling agent. SOLUTION: In an ophthalmic preparation containing menthol as a cooling agent, brimonidine is blended to reduce the cytotoxicity of menthol as a cooling agent and to enhance the cooling sensation of menthol. I found out. Furthermore, in ophthalmic preparations containing brimonidine and a cooling agent selected from the group consisting of bergamot oil, geraniol and borneol, the cytotoxicity caused by the cooling agent can be similarly reduced by adding brimonidine. shown. Based on the above results, an ophthalmic formulation containing a cooling agent and brimonidine is provided. [Selection drawing] Fig. 2 |