| abstract |
PROBLEM TO BE SOLVED: To provide a morphinan derivative having an opioid κ receptor agonist action. SOLUTION: A morphinan derivative represented by the following general formula (I). ( In the formula , R 1 to R 1 1 are hydrogen atoms, C 1-6 alkyl groups which may have substituents, etc., R 12 and R 13 are hydrogen atoms, etc., R 14 are heteroaryl groups, etc. , X is a nitrogen atom or the like, Y or Z is an oxygen atom or the like, m is an integer of 0 to 1, and n is an integer of 0 to 3). [Selection diagram] None |