abstract |
PROBLEM TO BE SOLVED: To provide an oligomer compound having a conjugated group targeting an apolipoprotein (a) [apo (a)]. A compound containing a modified oligonucleotide and a conjugate group, wherein the modified oligonucleotide consists of 12 to 30 linked nucleobases and complements the equal length portion of a particular nucleobase of a particular base sequence. Provided is a compound comprising a nucleobase sequence comprising a portion of at least eight contiguous nucleobases, wherein the nucleobase sequence of the modified oligonucleotide is at least 80% complementary to the particular nucleobase. .. [Selection diagram] None |