abstract |
PROBLEM TO BE SOLVED: To provide a human immunodeficiency virus neutralizing antibody. An isolated monoclonal antibody or antigen-binding fragment thereof comprising heavy chain complementarity determining regions 1 to 3 (CDRs 1 to 3) and light chain CDRs 1 to 3 consisting of a specific sequence, said antibody or. The antigen-binding fragment contains between 0 and 4 amino acid substitutions in the CDRs and: a. IgG1m17 allotype heavy chain; b. Lambda 2 light chain; c. Heavy chain constant regions containing amino acid substitutions at specific positions; as well as d. Heavy chain variable comprising one or more of Ser-Ser-Val or Thr-Gly-Val, Gln, Asn, His, Lys, His or Thr, Leu, Ala, and Ala at a particular site. Provided is a monoclonal antibody or an antigen-binding fragment thereof comprising one or more of the regions. [Selection diagram] None |