| abstract |
As used herein, a phenoxy-pyridyl-pyrimidine compound having an inositol-requiring enzyme 1 (IRE1) -regulating activity or function having the structure of Formula I. Or their stereoisomers, tautomers, or pharmaceutically acceptable salts, as well as those having the substituents described herein and their structural features. Also, pharmaceutical compositions and drugs containing compounds of Formula I, and such IRE1 modulators alone and in combination with other therapeutic agents, to treat diseases or conditions mediated by or dependent on the estrogen receptor. The method used is also described. |