http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2021536475-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D277-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-021 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-1077 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H15-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-1024 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-05 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D277-56 |
| filingDate | 2019-09-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-12-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2021536475-A |
| titleOfInvention | Alternative process for the preparation of tubelysine and its intermediates |
| abstract | An improved process for the preparation of tubular lysine compounds, tubular lysine drug linker compounds, and their intermediates is disclosed. The present invention provides a method for preparing a composition comprising a tubevalin compound in salt form, if desired, wherein the method is (a) contacting in a suitable polar aprotic solvent, (a). b) A step of forming an optical isomer mixture of tubevalin intermediates in salt form, or a composition containing this mixture, by quenching the reaction mixture with Bronsted acid, (c) the optical isomer mixture. The step of forming a composition containing an essentially equimolar mixture of diastereomers by contact with a suitable chiral reducing agent, (c') separating the diastereomers from the composition of the diastereomeric mixture. Including the step of obtaining a composition. |
| priorityDate | 2018-09-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 395.