http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2021534233-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-255 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-19 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0019 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-205 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-255 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P7-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P7-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-40 |
| filingDate | 2018-08-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-12-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2021534233-A |
| titleOfInvention | Busulfan composition and its preparation method and use |
| abstract | What is disclosed in the present invention is a busulfan composition and a method and application thereof. The busulfan composition is included such that the busulfan: cyclodextrin is 1-20: 100-2000. Preferably, the busulfan composition is prepared by dissolving busulfan in an organic solvent to prepare a busulfan solution having a concentration of 1 to 20 mg / mL, and dissolving SBE-β-cyclodextrin in water for injection to 10 to 40%. The step of preparing the SBE-β-cyclodextrin aqueous solution (w / v), the step of mixing the two solutions in a nitrogen atmosphere, stirring for 1 hour, and then removing the organic solvent, and the steps of filtering and freezing and drying are performed. Prepared by the method including. The present invention is used for tablets and injections. Studies have demonstrated that the present invention can significantly improve the stability of busulfan. The injections of the present invention are less irritating and can be used for clinical injections, improving drug safety while ensuring product stability. |
| priorityDate | 2018-08-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 48.