http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2021534124-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D491-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D491-107 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-506 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D491-107 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-513 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-02 |
| filingDate | 2019-08-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-12-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2021534124-A |
| titleOfInvention | 6- (4-Amino-3-methyl-2-oxa-8-azaspiro [4.5] decane-8-yl) -3- (2,3-dichlorophenyl) as an inhibitor of PTPN11 (SHP2) for the treatment of cancer -2-Methylpyrimidine-4 (3H) -one derivative and related compounds |
| abstract | The present invention is 6- (4-amino-3-methyl-2-oxa-8-azaspiro] useful as an inhibitor of PTPN11 (SHP2) for the treatment or prevention of cancer and other PTP-mediated diseases. 5] Decane-8-yl) -3- (2,3-dichlorophenyl) -2-methylpyrimidine-4 (3H) -one derivative and related compounds. The preferred compound is 6-((3S, 4S) -4-amino-3-methyl-2-oxa-8-azaspiro [4.5] decane-8-yl] having an IC50 of 3 nM in the PTPN11-E76K mutant enzyme inhibition assay. ) -3 (Ra)-(2,3-dichloro-4-((1-methyl-1H-pyrazole-3-yl) oxy) phenyl) -2,5-dimethylpyrimidine-4 (3H) -one (implemented) Example 18b) and the like. [Selection diagram] None |
| priorityDate | 2018-08-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 67.