| abstract |
Provided herein are, in particular, predictive, pharmacodynamic, and therapeutic methods for the treatment of breast cancer. In embodiments, the method and composition are at least partially sampled from an individual (eg, tissue sample, eg, tumor tissue sample, eg, FFPE sample, FF sample, archive sample, fresh sample, or frozen tumor tissue sample). Estradiol (E2) induction score or estrogen receptor (ER) pathway activity score determined from the method for determining whether an individual with breast cancer is likely to respond to treatments including endocrine therapy, an individual with breast cancer. Based on the findings that it can be used in methods of selecting therapy for, treating individuals with breast cancer, and monitoring the therapeutic effects of endocrine therapy, as well as related kits. |