| abstract |
Aspects of the present disclosure relate to complexes comprising muscle targeting agents covalently linked to a molecular payload. In some embodiments, the muscle targeting agent specifically binds to internalized cell surface receptors on muscle cells. In some embodiments, the molecular payload inhibits the expression or activity of the DMPK allele, including disease-related repeats. In some embodiments, the molecular payload is an oligonucleotide, such as an antisense oligonucleotide or an RNAi oligonucleotide. |