http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2021527071-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D495-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D495-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-519 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0019 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-7064 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4365 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D495-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4365 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-06 |
| filingDate | 2019-06-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-10-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2021527071-A |
| titleOfInvention | Thieno [2,3-B] pyridine derivative as an EPAC inhibitor and its pharmaceutical use |
| abstract | The present invention is Chieno [2,3] for use in the treatment and / or prevention of diseases selected from the group consisting of inflammation, cancer, vascular disease, renal disease, cognitive impairment, pain, infectious disease, obesity and heart disease. -B] Regarding pyridine derivatives. In fact, we believe that the thieno [2,3-b] pyridine derivatives of the invention are inhibitors of the Epac protein and therefore may be useful in the prevention and / or treatment of diseases involving the Epac protein. I found. In particular, we have shown that the thieno [2,3-b] pyridine derivatives of the invention are potent, non-competitive inhibitors of Epac, and that they are downstream of Epac, such as Rap1 in cells. It was also demonstrated to inhibit the activation of effectors. |
| priorityDate | 2018-06-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
| Predicate | Subject |
|---|---|
| isDiscussedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID416134227 http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID1772579 |
Total number of triples: 23.