| abstract |
Provided herein are antibodies and antigen-binding fragments that bind to MSR1 and how to use them. According to one embodiment, the antibody binds to human MSR1 with high affinity. In certain embodiments, the antibody binds to MSR1 without or by blocking less than 90% of the modified LDL binding to MSR1. In some embodiments, the antibody binds to and is internalized to cell surface expression MSR1. The antibody of the present invention may be a fully human antibody. The present invention comprises an anti-MSR1 antibody or antigen-binding fragment thereof conjugated to a drug or therapeutic compound. [Selection diagram] FIG. 21 |