| abstract |
The present invention relates to the technical field of medicine, and relates to an immediate release pharmaceutical preparation of an anticoagulant and a method for producing the same. The immediate release pharmaceutical preparation of the anticoagulant comprises a bicagrel compound or a pharmaceutically acceptable form thereof, the preparation is in the form of tablets or capsules, and the bicagrel or the pharmaceutically acceptable form thereof is D90. It is provided with an appropriate particle size of <50 μm. The drug-containing particles obtained in the present invention exhibit a rapid release property when the pharmaceutical preparation formed therein exhibits a rapid release property in an in vitro dissolution test, and have a higher degree of drug absorption (AUC) and drug absorption rate in in vivo pharmacokinetics. There are considerable merits such as (Cmax). The present invention further comprises the formulation of the drug-containing particles disclosed in the present invention, which makes it possible to obtain an immediate release formulation of a capsule or tablet having excellent stability by any combination of preparation steps. It provides a method for preparing an immediate release pharmaceutical preparation. |