abstract |
The present invention is a compound of formula (I) [Chemical formula 1] that inhibits apoptosis signal regulatory kinase 1 (ASK-1) associated with autoimmune disease, neurodegenerative disease, inflammatory disease, chronic renal disease, and cardiovascular disease. , And their pharmaceutically acceptable salts and esters. The present invention further relates to pharmaceutical compositions containing the aforementioned compounds for administration to subjects suffering from ASK-1 related diseases. The present invention also relates to a method of treating an ASK-1-related disease in a subject by administering a pharmaceutical composition comprising the compound of the present invention. The present invention relates specifically to methods of treating ASK-1 associated with hepatic steatosis, including non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH). |