| abstract |
Compositions and methods for targeting and treating cancers that develop cancer and infections are disclosed. In particular, a chimeric antigen receptor (CAR) polypeptide that can be used in adoptive cell transfer to target and kill transformed and infected cells is disclosed. Immune effector cells such as T cells or natural killer (NK) cells that have been recombined to express the CAR are also disclosed. Accordingly, methods of providing immunotherapy in a subject with an infection or cancer, accompanied by adoption of the immunoeffector cells of the present disclosure recombinant to express the CAR of the present disclosure, are also disclosed. |