| abstract |
The present invention relates to a skin-permeable transmitter containing a nucleic acid complex having a novel structure capable of introducing a biologically active nucleic acid into a cell and a composition for diagnosing, preventing or treating a disease containing the same. The present invention relates to a skin-permeable transmitter containing a nucleic acid complex in which an active nucleic acid and a carrier peptide nucleic acid are complementarily bound and having skin permeability and skin persistence, and a composition for diagnosing, preventing or treating a disease containing the same. According to the present invention, a skin-permeable transmitter containing a nucleic acid complex having the structure of structural formula (1) simultaneously has a skin-penetrating function for effectively transmitting a drug having a large molecular weight and an efficacy in the body. .. The transmitter according to the present invention allows, in particular, the passage of bioactive nucleic acids or various compounds through the skin epidermis and dermis, and allows external treatment applied to the skin surface. [Selection diagram] Fig. 3 |