abstract |
The present invention provides a small molecule activated RNA composed of a sense oligonucleotide strand and an antisense oligonucleotide strand that activates or upregulates the expression of the human p21 gene. The sense strand or antisense strand has 75% or more homology with any of the contiguous fragments of the human p21 gene promoter target gene sequence having a length of 16-35 nucleotides. Among them, the target sequence of the human p21 gene is selected by a set consisting of the sequences shown in SEQ ID NOs: 5, 6, 7, 8, 9, 10, 11 and 12. |