| abstract |
Provided herein are triazacyclododecane sulfonamide (“TCD”)-based protein secretion inhibitors, such as inhibitors of Sec61, methods of their preparation, related pharmaceutical compositions, and the use thereof. How to do it. For example, provided herein are compounds of formula (I): [Chemical 1] And pharmaceutically acceptable salts, as well as compositions containing them. The compounds disclosed herein can be used, for example, in the treatment of diseases including inflammation and / or cancer. |