abstract |
The present invention relates to a double-stranded ribonucleic acid (dsRNA) composition that targets the HSD17B13 gene, a method of inhibiting the expression of HSD17B13, and a subject for which reduction of expression of HSD17B13 is expected to be beneficial, such as, for example. It relates to a method of treating a subject having a disease, disorder, or condition associated with HSD17B13, etc., using such a dsRNA composition. The present invention suffers from a subject for which inhibition or reduction of HSD17B13 gene expression is expected to be beneficial for inhibiting expression of the HSD17B13 gene and / or for a subject such as HSD17B13 related disease such as chronic fibroinflammatory liver disease. Also provided are methods of using the iRNA compositions of the invention for treating a subject who is or are susceptible. |