| abstract |
The present invention relates specifically to a method of producing an immunogenic composition exhibiting reduced viral killing activity, and the immunogenic composition and its use, the method particularly comprising (a) a first liquid and a set. The steps of providing a mixture having a replacement protein, (b) concentrating the recombinant protein in the mixture by removing a portion of the first liquid from the mixture, and (c) obtaining from step (b). The solution is treated by continuous dialysis filtration. |