| abstract |
The present invention provides the use of PRAK as a drug target in screening for drugs that suppress or prevent metastasis of tumor cells. The present invention provides a drug capable of further suppressing or preventing metastasis of tumor cells based on the discovery that PRAK targets metastasis of tumor cells, and the active ingredient of the drug lowers the expression level of PRAK or PRAK. By controlling cell migration, expression and / or function of molecules involved in HIF1α, MMP2 and / or EMT, the biological activity of tumor cells can be suppressed or prevented against metastasis. [Selection diagram] Fig. 6 |