| abstract |
The present invention relates to a nucleic acid complex having a novel structure capable of introducing a biologically active nucleic acid into a cell, a composition for treating or diagnosing a disease containing the nucleic acid complex, and a method for regulating target gene expression using the same. Nucleic acid complex in which a bioactive nucleic acid containing a substance that assists escape and a carrier peptide nucleic acid are complementarily bound, a composition for treating or diagnosing a disease containing the nucleic acid, a composition for regulating target gene expression, and target gene expression using the same. Regarding the adjustment method. The nucleic acid complex containing the bioactive nucleic acid and the carrier peptide nucleic acid according to the structural formula (1) of the present invention enhances the safety of the bioactive nucleic acid and causes loss such as precipitation due to self-aggregation of the bioactive nucleic acid. It can be reduced, the transmission efficiency of intracellular bioactive nucleic acids can be increased, and the expression of target genes can be easily regulated. In addition, the nucleic acid complex is useful for effectively exhibiting activity in the cytoplasm of the nucleic acid complex that has penetrated into the cell by internalization of the cell by containing a substance that assists endosome escape. [Selection diagram] FIG. 1A |