http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2021515029-A

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classificationCPCInventive http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-34
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4439
classificationIPCInventive http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-04
filingDate 2018-12-18-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 2021-06-17-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber JP-2021515029-A
titleOfInvention Separation of racemic nicotine enantiomer by addition of O, O'-disubstituted tartrate enantiomer
abstract In the present invention, racemic nicotine of formula (Ia) as a mixture of (R) -enantiomer and (S) -enantiomer is enantiomerically represented by formulas (Ib) and (Ic). With respect to the method of separating into pure (S)-and (R) -nicotine, the method is a mixture of L-enantiomers and D-enantiomers of O, O'-disubstituted tartaric acid, D of L-enantiomers. Add a mixture having a molar ratio of −enantiomer to 80:20 to 95: 5 to obtain (S) -nicotine of formula (1-b), or add O, O'-dibenzoyl-D-tartaric acid. By obtaining (R) -nicotine of formula (1-c).
priorityDate 2017-12-22-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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