| abstract |
The present disclosure relates to a compound having ferrotosis-inducing activity, a method for treating a subject having cancer using the compound, and a combination treatment with a second therapeutic agent. In certain embodiments, the compound is used in a method of inhibiting intracellular GPX4, comprising contacting the cell with an effective amount of a compound described herein to inhibit intracellular GPX4. To. In certain embodiments, the cell is a cancer cell. In certain embodiments, the compound is used in a method of treating cancer in a subject, comprising administering to the subject having cancer a therapeutically effective amount of a ferrotosis-inducing compound. |