| abstract |
The present invention provides mouse antibodies, chimeric antibodies and humanized antibodies that specifically bind to GPC3 and conjugates thereof. Anti-GPC3 antibodies and antibody-drug conjugates directed to GPC3 are provided herein. In particular, a tubelisin antibody-drug conjugate directed to GPC3 and a method of using such a conjugate to treat a disorder expressing GPC3 are provided herein. Preferred anti-GPC3 antibodies are chimeric or humanized forms of mouse GPC3-1 antibodies. The mouse GPC3-1 antibody comprises a heavy chain variable region having the amino acid sequence set forth in SEQ ID NO: 8 and a light chain variable region having the amino acid sequence set forth in SEQ ID NO: 9. |